Upper Demerara-Berbice (Region 10) is a region of Guyana, bordering the regions of Essequibo Islands-West Demerara, Demerara-Mahaica and Mahaica-Berbice to the north, the region of East Berbice-Corentyne to the east, and the regions of Potaro-Siparuni and Cuyuni-Mazaruni to the west.

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