Pánuco is a city in the Mexican state of Veracruz, located in the state’s Huasteca Alta region. It serves as the municipal seat of the surrounding Pánuco Municipality. It stands on the banks of the Río Pánuco. Pánuco is traditionally held to have been founded by Hernán Cortés on 22 December 1522, as Villa de Santiesteban del Puerto, the second ayuntamiento on the American continent. It was the capital of the Province of Pánuco in the early colonial period. It was given city status on 30 June 1931.

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