Mytilene is a town and a former municipality on the island of Lesbos, North Aegean, Greece. Since the 2011 local government reform it is part of the municipality Lesbos, of which it is a municipal unit. It is the capital of the island of Lesbos. Mytilene, whose name is pre-Greek, is built on the southeast edge of the island. It is also the seat of a metropolitan bishop of the Orthodox church.
Mytilene is linked with a highway numbered (GR-67) linking to Skala Eressou on the other side of the island of Lesbos. Farmlands surround Mytilene, the mountains cover the west and to the north. The airport is located a few kilometres south of town. The City was called Midilli during Ottoman times.
It is located in the southeastern part of the island, north and east of the Bay of Gera. It has a land area of 107.46 square kilometres (41.49 sq mi) and a population of 36,196 inhabitants (2001). With a population density of 336.8/km² it is by far the most densely populated municipal unit in Lesbos. The next largest towns in the municipal unit are Vareiá (pop. 1,254), Pámfila (1,247), Mória (1,207), and Loutrá (1,118).

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