Missolonghi is a town of about 13,000 people (2001) in western Greece. The town is the capital of Aetolia-Acarnania and is also its third largest town. It is the seat of the municipality of Iera Poli Mesolongiou (Sacred City of Missolonghi). Missolonghi is linked to, although bypassed since the 1960s by, GR-5/E55. The road to Astakos is to the northwest and there is also access to GR-48 to the east. The town had a railway station on the line to Agrinio but this has been abandoned since the 1970s.
The town is located between the Acheloos and the Evinos rivers and has a port on the Gulf of Patras. It trades in fish, wine, and tobacco. The Arakynthos mountains lie to the northeast. The town is almost canalized but houses are within the gulf and the swamplands. The Messolonghi-Etoliko Lagoons complex lies to the west and is also a swampy area. In the ancient times, the land was part of the gulf.

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