Guisa is a municipality and city in the Granma Province of Cuba. It is located 19 kilometres (12 mi) south-east of Bayamo, the provincial capital. In 2003, the municipality of Guisa had a population of 50,923. With a total area of 596 km2 (230 sq mi), it has a population density of 85.4 /km2 (221 /sq mi).

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