Darién is a province in eastern Panama. It is also the largest province in Panama. It is hot, humid, heavily forested, and sparsely populated, having 48,378 habitants (2010.) Europeans first discovered the region in 1501, and Christopher Columbus sighted it on his fourth voyage in 1503. The Spanish established the first European colony in South America, Santa María la Antigua del Darién, in Darién in 1510. The settlement did not prosper, however, and was soon abandoned. Some of the refugees from Santa María went on to found Panama City in 1519. From upon a peak near Santa Maria in present-day Darién during 1513, Panama, Vasco Núñez de Balboa became the first European known to have seen the Pacific Ocean from the New World.

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