Grand-Santi is a commune of French Guiana, an overseas region and department of France located in South America. The commune was originally called Grand-Santi-Papaichton and included the now independent communes of Apatou and Papaichton. On 12 November 1976 Apatou was detached from Grand-Santi-Papaichton and became an independent commune. On 1 January 1993 Papaichton was also detached from Grand-Saint-Papaichton and became an independent commune. On that occasion, the name of the commune was shortened into Grand-Santi. The Grand-Santi Airport is located 1 km (0.54 NM) northeast of Grand-Santi.

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