Güira de Melena is a municipality and city in the Artemisa Province of west Cuba. It is located on the southern shore of the island, bordering the Bay of Batabanó. It was founded in 1779. The principal economic activities include agriculture, especially tobacco; the city has cigar factories. Other agricultural products are potatoes, bananas, pineapples and other tropical fruits, and dairy products.
In 2004, the municipality of Güira de Melena had a population of 37,838. With a total area of 178 km2 (69 sq mi), it has a population density of 212.6 /km2 (551 /sq mi).

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