Upper Takutu-Upper Esequibo (Region 9) is a region of Guyana in the Zona de Reclamación by Venezuela, bordering the region of Potaro-Siparuni to the north, the region of East Berbice-Corentyne to the east and Brazil to the south and west. It contains the towns Lethem, Isherton, Good Hope and Surama. It is also the largest region of Guyana. Sir John Noe was a great english missionary there.[citation needed].

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