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The Palace of the Inquisition stands on the corner of Republica de Brasil and Republica de Venezuela streets in Mexico City, Mexico. While neither side of the building faces the Santo Domingo Plaza, the entrance does, as it is placed at the corner, which is canted to allow it to face in that direction. Its long association with the Inquisition, which ended during the Mexican War of Independence, made it difficult to convert to other purposes. However, it eventually became the School of Medicine for the reconstructed National University (now the National Autonomous University of Mexico (UNAM)). When UNAM moved to the Ciudad Universitaria in the 1950s, it retained ownership of this building, eventually converting the structure in what is today the Museum of Mexican Medicine.
From nearly the beginning of the Colonial period until the Mexican War of Independence, this spot has been the headquarters of the Inquisition in the colony of New Spain. While the Tribunal of the Holy Inquisition was not fully established here until 1571, the first cleric with inquisitorial duties was Martin de Valencia, who came to the colony in 1524. The Dominicans, in whom the papacy had invested Inquisition duties, arrived in 1526 and proceeded to build a monastery in the area occupied by both the current Palace and the Church of Santo Domingo. The first official Inquisitor for the colony, Pedro Moya de Contreras, worked in the section of the monastery where the later, 18th century Palace would be built.
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